Published November 18, 2025 | Version 1.0
Preprint Open

A Physical Model for Regulation-First in the Proto-Liver Origin of Life (PLOL) Framework

  • 1. Independant Researcher, New Zealand

Contributors

  • 1. OpenAi
  • 2. XAi

Description

The Proto-Liver Origin of Life (PLOL) hypothesis argues that regulation was the first functional step toward life. This companion paper develops a mechanistic model describing how a primitive regulator could naturally arise in prebiotic environments through sunlight-driven redox asymmetry, mineral microcavities, and wet–dry cycling. These structures form energy-buffering microreactors capable of stabilizing electron flow and selecting molecules that improve regulatory control. This regulator-first model provides a physically grounded precursor to metabolism, compartmentalization, and replication, and establishes continuity between geological redox systems and modern hepatic function.

Notes (English)

This companion paper to the Proto-Liver Origin of Life (PLOL) framework presents a detailed mechanistic model explaining how the earliest regulator could emerge in prebiotic environments. It describes how sunlight, mineral microcavities, redox asymmetries, and wet–dry cycles naturally produce energy-buffering structures capable of stabilizing electron flow. These proto-regulators represent geological ancestors of homeostasis, metabolism, and eventually the liver. This work extends the PLOL framework and links early Earth geochemistry with modern hepatic physiology.

Files

A Physical Model for Regulation-First in the Proto-Liver Origin of Life PLOL Framework.pdf

Additional details

Related works

Is supplement to
Preprint: 10.5281/zenodo.17619803 (DOI)
Preprint: 10.5281/zenodo.17544611 (DOI)
Preprint: 10.5281/zenodo.17624518 (DOI)
Preprint: 10.5281/zenodo.17629009 (DOI)
Preprint: 10.5281/zenodo.17622231 (DOI)

Dates

Submitted
2025-11-18
Hypothesis Conceived and published